19 days old

Senior Associate Scientist PKDM

South San Francisco, CA 94080
  • Job Code

Job ID: R-116715
Location: South San Francisco, CA, US


You've earned your degree. How will you use that achievement to reach your goals? Do more with the knowledge you've worked hard to acquire and the passion you already have. At Amgen, our shared mission-to serve patients-drives all that we do. It is key to our becoming one of the world's leading biotechnology companies, reaching over 10 million patients worldwide. Become the professional you are meant to be in this meaningful role.

Senior Associate Scientist, Pharmacokinetics & Drug Metabolism (PKDM)


What you will do

Let's do this. Let's change the world. In this vital role you will add scientific expertise to the discovery and non-clinical development of small molecule therapeutics by carrying out in vitro ADME assays with a primary focus on drug transporters.

You will be primarily responsible for establishing, optimizing and trouble-shooting transporter screening assays to evaluate new chemical entities as substrates or inhibitors of drug transporters. You will also be contributing to the investigative work aimed towards improving our understanding of the role of drug transporters as they relate to absorption, distribution, and clearance of small molecule therapeutics.

  • Plan, conduct, analyze, interpret, and communicate results generated from transporter studies.
  • Independently design and execute transporter and potentially other in vitro ADME studies which may include screening as well as mechanistic studies.
  • Evaluate and implement emerging in vitro and in silico tools to support the prediction of transporter-mediated pharmacokinetics (PK) and drug interactions (DDIs) in humans.
  • Design and complete IND and NDA-enabling studies and report writing to support regulatory submissions. Additionally, you may have the opportunity to interact with contract research organizations (CROs).
  • Contribute to the implementation of new assays/techniques based on portfolio needs. Opportunities will be available to contribute to evaluation of ground breaking technology emerging in the field to provide answers to ADMET questions.
  • The candidate is expected to be a great teammate, independent thinker and able to work in a highly collaborative, fast pace environment.

Your specific contributions will depend on your expertise, interests, training, and experience. You will also have opportunities to learn and obtain experience with PKDM strategies for the discovery and non-clinical development of multiple therapeutic modalities.

A collaborative and highly capable scientific community at Amgen is available to support these efforts. Interactions and collaborations with academic and other external scientists are encouraged.


What we expect of you

We are all different, yet we all use our unique contributions to serve patients. The scientific professional we seek is a go getter with these qualifications.

Required Qualifications

Master's degree


Bachelor's degree and 2 years of Scientific experience

Preferred Qualifications
  • Experience in transporter assays and cell culture handling
  • Experience with TECAN automation, mass-spectrometry based and radiometric analysis
  • Hepatocyte handling experience
  • Experience in drug discovery and/or development programs; expertise with implementing, optimizing and troubleshooting in vitro transporter assays; and demonstrated ability to communicate with team members across broad disciplines and geographical locations
  • Effective oral and written communication skills


Some of the vast rewards of working here

As we work to develop treatments that take care of others, so we work to care for our teammates' professional and personal growth and well-being.
  • Full support and career-development resources to expand your skills, enhance your expertise, and maximize your potential along your career journey
  • A diverse and inclusive community of belonging, where teammates are empowered to bring ideas to the table and act
  • Generous Total Rewards Plan-comprising health, finance and wealth, work/life balance, and career benefits-with compensation and benefits rated above 4 stars (out of 5) on Glassdoor

Apply now for a career that defies imagination

Objects in your future are closer than they appear. Join us.


Equal Opportunity Statement

Amgen is an Equal Opportunity employer and will consider you without regard to your race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, or disability status.

We will ensure that individuals with disabilities are provided a reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us to request an accommodation.

Join Us

If you're seeking a career where you can truly make a difference in the lives of others, a career where you can work at the absolute forefront of biotechnology with the top minds in the field, you'll find it at Amgen.

Amgen, a biotechnology pioneer, discovers, develops and delivers innovative human therapeutics. Our medicines have helped millions of patients in the fight against cancer, kidney disease, rheumatoid arthritis and other serious illnesses.

As an organization dedicated to improving the quality of life for people around the world, Amgen fosters an inclusive environment of diverse, ethical, committed and highly accomplished people who respect each other but compete intensely to win. Together, we live the Amgen values as we continue advancing science to serve patients.

Amgen is an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, or disability status.

Amgen will consider for employment qualified applicants with criminal histories in a manner consistent with the San Francisco Fair Chance Ordinance.



Posted: 2021-04-18 Expires: 2021-05-19

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Senior Associate Scientist PKDM

South San Francisco, CA 94080

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