18 days old

Scientist I

Seattle, Washington 98102
  • Job Code
  • Job Type
  • Job Status
    Full Time

The Infectious Disease Research Institute (IDRI) is a Seattle-based not-for-profit organization committed to applying innovative science to the research and development of products to prevent, detect and treat infectious diseases. IDRI translates basic research to develop vaccines, diagnostics and drugs for applications in global health. We focus on antigen discovery and development, adjuvant formulation and delivery, drug discovery and development, and biomarker discovery for diagnostics. IDRI’s leadership in the global health community extends to international alliances and partnerships with pharmaceutical and biotechnology companies, universities, research institutes, governments, and public health organizations.


The TB Discovery Group is looking for a Scientist I to work in the drug discovery group. The successful candidate will be responsible for projects utilizing high throughput screening (including high content screens) to identify and progress novel chemical series. The successful candidate will work in a multi-disciplinary research environment, interacting with chemists, biochemists, and microbiologists on multiple projects. The candidate will be involved at all stages of drug discovery in evaluating and translating screening “hits” into lead compounds for development into pre-clinical TB drug candidates. The project will utilize sophisticated high throughput microscopy to identify compounds that potentiate intracellular bacterial killing, as well as determine mode of action of novel agents.



  • Graduate in relevant biological science
  • PhD in relevantarea
  • Laboratory benchskills
  • Good communicationskills
  • Computer literacy, including word processing, Excel and literaturesearches
  • Scientific publicationrecord


Primary Responsibilities:

  • Work under Biosafety Level 3 conditions with Mycobacteriumtuberculosis
  • Conduct a research and development project using high throughputscreening
  • Conduct research to understand mode of action of novel anti-mycobacterialcompounds
  • Run a wide range of microbiological and cellularassays
  • To coordinate and direct drug discovery projects with internal and externalpartners
  • Design and implement researchplans
  • Troubleshoot and solve experimental and technicalproblems
  • Writing standard protocols and validation datapackages
  • Liaising with externalcollaborators
  • Write manuscripts and assist with grantpreparation
  • Contributefreelytotheteamresearchenvironmentinamannerconducivetothesuccessofthe research project as awhole

Specific duties include:

  • Establishingandusinghighthroughputmethodstomonitorintracellularreplicationofmycobacteriaand trackcytotoxicity
  • Genetic manipulation and culture ofmycobacteria
  • Implementation of assays to determine key pathways and mode of action ofcompounds
  • Data analysis and parameter selection forassays
  • Oversee quality control and dataintegrity


Knowledge, Skills and Abilities:


Essential Skills

  • Graduate in relevant biological science
  • PhD in relevantarea
  • Laboratory benchskills
  • Good communicationskills
  • Computer literacy, including word processing, Excel and literaturesearches
  • Scientific publicationrecord


Desirable skills

  • Expertise in high throughput assaydevelopment
  • Expertise in microbial genetics and/or cellularassays
  • Experience working with mycobacteria or otherpathogens
  • Biosafety level 3 (BSL3)experience



  • Ability to work with hazardous organisms at BSL3level
  • Ability to maintain good laboratoryrecords
  • Ability to organize and prioritize ownwork
  • Ability to writepapers
  • Ability to generate scientifichypotheses
  • Ability to work effectively in collaborative laboratory environment with multiple ongoingprojects
  • Ability to work with co-workers and outside agencies professionally andtactfully
  • Ability to maintain confidentiality of sensitiveinformation
  • Willingness to learn newskills
  • Possess a work ethic that includes neatness, punctuality, andaccuracy
  • Excellent oral and written communication skills in English.


IDRI offers a comprehensive compensation plan which includes Medical, Dental, Vision, Life, AD&D and EAP. In addition, IDRI offers Flexible Spending Accounts, a matching ROTH 401K Retirement Plan and Commuter benefits.


Infectious Disease Research Institute (IDRI) is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, gender, gender identity or expression, sexual orientation, national origin, genetics, disability, age, or veteran status.


Posted: 2019-10-25 Expires: 2019-11-24

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Scientist I

Seattle, Washington 98102

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